Heme-protein platform

Producing proteins whose function depends on heme.

Synfera develops production approaches for complex heme proteins. We combine protein engineering and precision fermentation to pursue useful material for internal products and partner programmes.

Why heme proteins

A broad protein class with demanding production biology.

Heme proteins use an iron-containing cofactor to perform functions that include gas transport, electron transfer, catalysis, and sensing. Their utility is broad, but producing a correctly assembled and functional protein can be technically demanding.

What are heme proteins?
Production challenge

Function requires more than expression.

Every target is different. Synfera begins with the protein, application, and evidence needed rather than offering a one-size-fits-all catalogue.

01

Protein architecture

Many heme proteins depend on precise folding, assembly, and cofactor incorporation. Production has to account for the complete functional structure, not sequence alone.

02

Heme incorporation

The heme cofactor is central to function. A useful production strategy must support both the protein and the chemistry that gives it activity.

03

Application fit

The right expression and preparation approach depends on the target protein, intended use, development stage, and material requirements.

Flagship demonstration

Erythrocruorin is where the platform began.

Synfera's work on the extracellular oxygen-carrying protein erythrocruorin led to Aerus, our first product programme. It remains a focused example of the complex heme proteins we aim to produce.

Work with Synfera

Start with the protein you need.

We welcome early conversations with biotechnology teams, researchers, and strategic partners. An inquiry starts a technical discussion and feasibility review; it does not guarantee capacity, timing, or project acceptance.

01

Define

Share the target, intended application, current construct, and the questions the material needs to answer.

02

Assess

Synfera reviews technical fit and identifies the information needed for a potential feasibility programme.

03

Propose

Where there is a fit, the teams define a scoped collaboration with clear objectives and next steps.

Discuss a heme-protein project